Article
Genetic Variants of IκB Kinase β (IKBKB) and Polymerase β (POLB) Were Not Associated with Systemic Lupus Erythematosus Risk in a Chinese Han Population.
PloS one - 1 Jan 2015
Li Yuan, Wu Ziyan, Zhang Shulan, Chen Si, Li Ping, Li Jing, Cao Chongwei, Liu Bin, Zhang Fengchun, Li Yongzhe
Abstract excerpt
A previous large-scale replication study validation of a genome wide association study (GWAS) identified IκB kinase β (IKBKB) single nucleotide polymorphisms (SNPs) as a risk factor associated with systemic lupus erythematosus (SLE) in a Chinese Han population. IKBKB SNPs were associated with polymerase β (POLB) SNPs and reduced POLB expression, and this was proposed to be an underlying cause of human SLE...
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