Article
A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation.
The Journal of biological chemistry - 4 Sept 2015
Meyer N Helge, Mayerhofer Hubert, Tripsianes Konstantinos, Blindow Silke, Barths Daniela, Mewes Astrid, Weimar Thomas, Köhli Thies, Bade Steffen, Madl Tobias, Frey Andreas, Haas Helmut, Mueller-Dieckmann Jochen, Sattler Michael, Schramm Gabriele
Abstract excerpt
The IL-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1), the major secretory product of eggs from the parasitic worm S. mansoni, efficiently triggers basophils to release the immunomodulatory key cytokine interleukin-4. Activation by IPSE/α-1 requires the presence of IgE on the basophils, but the detailed molecular mechanism underlying activation is unknown. NMR and crystallographic analysis of...
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