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Cellular plasticity regulated cancer stem cell niche: a possible new mechanism of chemoresistance

23 Oct 2014

Abstract excerpt

The cancer stem cell (CSC) theory is an emerging concept that proposes a hierarchical nature of carcinogenesis, where a small number of tumor cells are capable of driving tumor growth. Despite many unanswered questions surrounding the cancer stem cell model, the hypothesis has rejuvenated hopes for formulating a novel therapeutic strategy for targeting the roots of cancer. This model predicts that cancer stem...

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PMID: 26161429
DOI: 10.14800/ccm.295

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