Article
Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes.
Computational and mathematical methods in medicine - 1 Jan 2015
Bozkurt Yasemin, Demir Alper, Erman Burak, Gül Ahmet
Abstract excerpt
Familial mediterranean fever (FMF) and Cryopyrin associated periodic syndromes (CAPS) are two prototypical hereditary autoinflammatory diseases, characterized by recurrent episodes of fever and inflammation as a result of mutations in MEFV and NLRP3 genes encoding Pyrin and Cryopyrin proteins, respectively. Pyrin and Cryopyrin play key roles in the multiprotein inflammasome complex assembly, which regulates...
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