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Article

Cryopyrin-associated periodic syndromes: diagnosis and management.

Paediatric drugs - 1 Apr 2012

Miyamae Takako

Abstract excerpt

Cryopyrin-associated periodic syndromes (CAPS) are a group of rare autoinflammatory disorders; many cases of CAPS are caused by mutations in the NLRP3 gene. In these conditions, interleukin (IL)-1 is overproduced, and this overproduction plays a major role in disease onset and progression. CAPS include three variants, ranging in order of increasing severity from familial cold autoinflammatory syndrome, previously...

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Identifiers

PMID: 22335455
DOI: 10.2165/11595040-000000000-00000

Genes

CAPS
NLRP3

Provenance

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