Article
The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors.
Biochemical Society transactions - 1 Aug 2002
Armour K L, Atherton A, Williamson L M, Clark M R
Abstract excerpt
A virally encoded, high-affinity Fc receptor (FcR) is found on herpes simplex virus type 1 (HSV-1) particles and infected cells where its binding of non-immune IgG protects cells from host-mediated lysis. Whilst mutation or aglycosylation of the IgG CH2 domain reduced binding to human FcR, the interaction with HSV-1 FcR was not affected. However, the HSV-1 FcR, unlike human FcR, discriminates between human IgG1...
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