Article
Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?
BMC genetics - 11 Jul 2015
Galesloot Tessel E, Janss Luc L, Burgess Stephen, Kiemeney Lambertus A L M, den Heijer Martin, de Graaf Jacqueline, Holewijn Suzanne, Benyamin Beben, Whitfield John B, Swinkels Dorine W, Vermeulen Sita H
Abstract excerpt
BACKGROUND: Previous reports suggested a role for iron and hepcidin in atherosclerosis. Here, we evaluated the causality of these associations from a genetic perspective via (i) a Mendelian randomization (MR) approach, (ii) study of association of atherosclerosis-related single nucleotide polymorphisms (SNPs) with iron and hepcidin, and (iii) estimation of genomic correlations between hepcidin, iron and...
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