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Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis.

Neurobiology of aging - 1 Feb 2024

Chen Keying, Gao Tongyu, Liu Ying, Zhu Kexuan, Wang Ting, Zeng Ping

Abstract excerpt

Current genome-wide association studies of frontotemporal dementia (FTD) are underpowered due to limited samples. Further, common genetic etiologies between FTD and amyotrophic lateral sclerosis (ALS) remain unknown. Using the largest summary statistics of FTD (3526 cases and 9402 controls) and ALS (27,205 cases and 110,881 controls), we found a significant genetic correlation between them (rˆg = 0.637,...

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PMID: 37979250
DOI: 10.1016/j.neurobiolaging.2023.09.017

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