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Compartmentalized Signaling in Aging and Neurodegeneration

22 Feb 2021

Abstract excerpt

The cyclic AMP (cAMP) signalling cascade is necessary for cell homeostasis and plays important roles in many processes. This is particularly relevant during ageing and age-related diseases, where drastic changes, generally decreases, in cAMP levels have been associated with the progressive decline in overall cell function and, eventually, the loss of cellular integrity. The functional relevance of reduced cAMP is...

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PMID: 33671541
DOI: 10.3390/cells10020464

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