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Article

BRCA1/2 sequence variants of uncertain significance: a primer for providers to assist in discussions and in medical management.

The oncologist - 1 Jan 2013

Lindor Noralane M, Goldgar David E, Tavtigian Sean V, Plon Sharon E, Couch Fergus J

Abstract excerpt

INTRODUCTION: DNA variants of uncertain significance (VUS) are common outcomes of clinical genetic testing for susceptibility to cancer. A statistically rigorous model that provides a pathogenicity score for each variant has been developed to aid in the clinical management of patients undergoing genetic testing. METHODS: The information in this article is derived from multiple publications on VUS in BRCA genes,...

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Identifiers

PMID: 23615697
DOI: 10.1634/theoncologist.2012-0452
PMCID: PMC3662842

Genes

BRCA1
BRCA2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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BRCA1/2 sequence variants of uncertain significance: a primer for providers to assist in discussions and in medical management.PMID 23615697Read ↗

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