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Article

Treatment of MDR1 mutant dogs with macrocyclic lactones.

Current pharmaceutical biotechnology - 1 May 2012

Geyer Joachim, Janko Christina

Abstract excerpt

P-glycoprotein, encoded by the multidrug resistance gene MDR1, is an ATP-driven drug efflux pump which is highly expressed at the blood-brain barrier of vertebrates. Drug efflux of macrocyclic lactones by P-glycoprotein is highly relevant for the therapeutic safety of macrocyclic lactones, as thereby GABA-gated chloride channels, which are confined to the central nervous system in vertebrates, are protected from...

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PMID: 22039792
DOI: 10.2174/138920112800399301
PMCID: PMC3419875

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