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Article

Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction.

Structure (London, England : 1993) - 4 Aug 2015

Chappell Paul E, Garner Lee I, Yan Jun, Metcalfe Clive, Hatherley Deborah, Johnson Steven, Robinson Carol V, Lea Susan M, Brown Marion H

Abstract excerpt

CD6 is a transmembrane protein with an extracellular region containing three scavenger receptor cysteine rich (SRCR) domains. The membrane proximal domain of CD6 binds the N-terminal immunoglobulin superfamily (IgSF) domain of another cell surface receptor, CD166, which also engages in homophilic interactions. CD6 expression is mainly restricted to T cells, and the interaction between CD6 and CD166 regulates...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26146185
DOI: 10.1016/j.str.2015.05.019
PMCID: PMC4533223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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