Article
Review and Hypothesis. New insights into the reaction mechanism of transhydrogenase: Swivelling the dIII component may gate the proton channel.
FEBS letters - 22 Jul 2015
Jackson J Baz, Leung Josephine H, Stout Charles D, Schurig-Briccio Lici A, Gennis Robert B
Abstract excerpt
The membrane protein transhydrogenase in animal mitochondria and bacteria couples reduction of NADP⁺ by NADH to proton translocation. Recent X-ray data on Thermus thermophilus transhydrogenase indicate a significant difference in the orientations of the two dIII components of the enzyme dimer (Leung et al., 2015). The character of the orientation change, and a review of information on the kinetics and...
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