Article
The role of invariant amino acid residues at the hydride transfer site of proton-translocating transhydrogenase.
The Journal of biological chemistry - 12 May 2006
Brondijk T Harma C, van Boxel Gijs I, Mather Owen C, Quirk Philip G, White Scott A, Jackson J Baz
Abstract excerpt
Transhydrogenase couples proton translocation across a membrane to hydride transfer between NADH and NADP+. Previous x-ray structures of complexes of the nucleotide-binding components of transhydrogenase ("dI2dIII1" complexes) indicate that the dihydronicotinamide ring of NADH can move from a distal position relative to the nicotinamide ring of NADP+ to a proximal position. The movement might be responsible for...
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