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Article

RNA Editing of the GP Gene of Ebola Virus is an Important Pathogenicity Factor.

The Journal of infectious diseases - 1 Oct 2015

Volchkova Valentina A, Dolnik Olga, Martinez Mikel J, Reynard Olivier, Volchkov Viktor E

Abstract excerpt

Synthesis of the surface glycoprotein GP of Ebola virus (EBOV) is dependent on transcriptional RNA editing, whereas direct expression of the GP gene results in synthesis of nonstructural secreted glycoprotein sGP. In this study, we investigate the role of RNA editing in the pathogenicity of EBOV using a guinea pig model and recombinant guinea pig-adapted EBOV containing mutations at the editing site, allowing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26138826
DOI: 10.1093/infdis/jiv309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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