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Article

Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs.

PLoS medicine - 1 Jun 2006

Sullivan Nancy J, Geisbert Thomas W, Geisbert Joan B, Shedlock Devon J, Xu Ling, Lamoreaux Laurie, Custers Jerome H H V, Popernack Paul M, Yang Zhi-Yong, Pau Maria G, Roederer Mario, Koup Richard A, Goudsmit Jaap, Jahrling Peter B, Nabel Gary J

Abstract excerpt

BACKGROUND: Ebola virus causes a hemorrhagic fever syndrome that is associated with high mortality in humans. In the absence of effective therapies for Ebola virus infection, the development of a vaccine becomes an important strategy to contain outbreaks. Immunization with DNA and/or replication-defective adenoviral vectors (rAd) encoding the Ebola glycoprotein (GP) and nucleoprotein (NP) has been previously...

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Share to Adenoviridae
Share to Dose-Response Relationship, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ebolavirus

Share to Hemorrhagic Fever, Ebola

Share to Macaca fascicularis

Share to Nucleoproteins

Share to Vaccination

Share to Vaccines, DNA

Source

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Identifiers

PMID: 16683867
DOI: 10.1371/journal.pmed.0030177
PMCID: PMC1459482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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