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Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level

7 Apr 2006

Abstract excerpt

Transient expression of Ebola virus (EBOV) glycoprotein GP causes downregulation of surface proteins, cell rounding and detachment, a phenomenon believed to play a central role in the pathogenicity of the virus. In this study, evidence that moderate expression of GP does not result in such morphological changes was provided. It was shown that GP continuously produced in 293T cells from the Kunjin virus replicon...

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PMID: 16603527
DOI: 10.1099/vir.0.81361-0

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