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Article

Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent Pregnancy Loss in Northern Europe.

PloS one - 1 Jan 2015

Nagirnaja Liina, Nõmmemees Diana, Rull Kristiina, Christiansen Ole B, Nielsen Henriette S, Laan Maris

Abstract excerpt

INTRODUCTION: Annexin A5 is an essential component of placental integrity that may potentially mediate susceptibility to phenotypes of compromised pregnancy. A promoter haplotype termed M2 of the coding gene ANXA5 has been implicated in various pregnancy complications such as preeclampsia and recurrent pregnancy loss (RPL), however with inconclusive results. STUDY SUBJECTS AND METHODS: A retrospective...

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Identifiers

PMID: 26135579
DOI: 10.1371/journal.pone.0131606
PMCID: PMC4489905

Genes

ANXA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent Pregnancy Loss in Northern Europe.PMID 26135579Read ↗

A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy lossSemantic proximity Read ↗

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Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications.Semantic proximity Read ↗

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Correlation of single nucleotide polymorphisms in the promoter region of the ANXA5 (annexin A5) gene with recurrent miscarriages in women of Greek origin.Semantic proximity Read ↗

Association between ANXA5 haplotypes and the risk of recurrent pregnancy loss.Semantic proximity Read ↗

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