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Article

Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications.

Journal of assisted reproduction and genetics - 1 May 2018

Aranda Federico, Udry Sebastián, Perés Wingeyer Silvia, Amshoff Lea Christina, Bogdanova Nadja, Wieacker Peter, Latino José Omar, Markoff Arseni, de Larrañaga Gabriela

Abstract excerpt

PURPOSE: Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29497952
DOI: 10.1007/s10815-018-1142-4
PMCID: PMC5984886

Genes

ANXA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications.PMID 29497952Read ↗

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Maternal and paternal carriage of the annexin A5 M2 haplotype: a possible risk factor for recurrent implantation failure (RIF).Semantic proximity Read ↗

Annexin A5 Promoter Haplotype M2 Is Not a Risk Factor for Recurrent Pregnancy Loss in Northern Europe.Semantic proximity Read ↗

Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele.Semantic proximity Read ↗

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A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy lossSemantic proximity Read ↗

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