Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of I30T and I30M substitution in MPZ gene associated with Dejerine-Sottas syndrome type B (DSSB): A molecular modeling and dynamics.

Journal of theoretical biology - 7 Oct 2015

Agrahari Ashish, George Priya Doss C

Abstract excerpt

Myelin protein zero (MPZ) gene encodes MPZ protein is a vital component of the myelin sheath. Mutationsassociated with MPZ gene leads to severe de-hypomyelination Dejerine-Sottas syndrome type B (DSSB) also termed as Charcot-Marie-Tooth disease (CMT) type 3. In this work, we employed a set of various in silico prediction methods to screen 97 nsSNPs associated with MPZ gene. Based on this, we identified the nsSNPs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to Hereditary Sensory and Motor Neuropathy

Share to Molecular Dynamics Simulation

Share to Mutant Proteins

Share to Myelin P0 Protein

Share to Protein Structure, Secondary

Source

Identifiers

PMID: 26135405
DOI: 10.1016/j.jtbi.2015.06.019

Genes

MPZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of I30T and I30M substitution in MPZ gene associated with Dejerine-Sottas syndrome type B (DSSB): A molecular modeling and dynamics.PMID 26135405Read ↗

Computational prioritization of deleterious human myelin protein zero gene mutations reveals structural disruption and potential myelin dysfunction through dynamic simulations and stability analysis.Semantic proximity Read ↗

In silico and in vitro effects of the I30T mutation on myelin protein zero instability in the cell membrane.Semantic proximity Read ↗

A computational approach to analyse the amino acid variants of GLB1 protein causing GM1 Gangliosidosis.Semantic proximity Read ↗

Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies.Semantic proximity Read ↗

In-silico screening and microsecond molecular dynamics simulations to identify single point mutations that destabilize β-hexosaminidase A causing Tay-Sachs disease.Semantic proximity Read ↗

Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and DiseaseSemantic proximity Read ↗

A profound computational study to prioritize the disease-causing mutations in PRPS1 gene.Semantic proximity Read ↗

Computational insights of K1444N substitution in GAP-related domain of NF1 gene associated with neurofibromatosis type 1 disease: a molecular modeling and dynamics approach.Semantic proximity Read ↗

Amyotrophic Lateral Sclerosis Type 20 - In Silico Analysis and Molecular Dynamics Simulation of hnRNPA1.Semantic proximity Read ↗

A comprehensive in silico analysis of multiple sclerosis related non-synonymous SNPs and their potential effects on protein structure and function.Semantic proximity Read ↗

Mechanistic insights into the deleterious role of nasu-hakola disease associated TREM2 variantsSemantic proximity Read ↗

Investigating the Structural Impact and Conformational Dynamics of a Sequence Variant (c.242G>A) in <i>TMIE</i> Gene Provoking Usher SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.