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Mosquitoes Reset Malaria Parasites

2 Jul 2015

Abstract excerpt

Serial blood passage of Plasmodium universally increases parasite virulence, which can be reversed by mosquito transmission.How mosquitoes reset Plasmodium virulence has been unknown.We have shown that mosquito transmission modifies expression of Plasmodium subtelomeric multigene families, including those that code for variant surface antigens (VSA), and transforms the systemic immune response to blood-stage...

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PMID: 26133171
DOI: 10.1371/journal.ppat.1004987

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