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Article

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015

Yuan Chen-Ching, Muthu Priya, Kazmierczak Katarzyna, Liang Jingsheng, Huang Wenrui, Irving Thomas C, Kanashiro-Takeuchi Rosemeire M, Hare Joshua M, Szczesna-Cordary Danuta

Abstract excerpt

Myosin light chain kinase (MLCK)-dependent phosphorylation of the regulatory light chain (RLC) of cardiac myosin is known to play a beneficial role in heart disease, but the idea of a phosphorylation-mediated reversal of a hypertrophic cardiomyopathy (HCM) phenotype is novel. Our previous studies on transgenic (Tg) HCM-RLC mice revealed that the D166V (Aspartate166 → Valine) mutation-induced changes in heart...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26124132
DOI: 10.1073/pnas.1505819112
PMCID: PMC4522794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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