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Article

Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.

Journal of neuroscience research - 1 Oct 2015

Hamm Matthew, Bailey Rachel, Shaw Gerry, Yen Shu-Hui, Lewis Jada, Giasson Benoit I

Abstract excerpt

Hyperphosphorylation and aggregation of tau are observed in multiple neurodegenerative diseases termed tauopathies. Tau has also been implicated in the pathogenesis of Parkinson's disease (PD) and parkinsonisms. Some PD patients with mutations in the leucine-rich repeat kinase 2 (LRRK2) gene exhibit tau pathology. Mutations in LRRK2 are a major risk factor for PD, but LRRK2 protein function remains unclear. The...

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Identifiers

PMID: 26123245
DOI: 10.1002/jnr.23614
PMCID: PMC4869353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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