Article
LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.
Biochemistry - 25 Aug 2015
Shanley Mary R, Hawley Dillon, Leung Shirley, Zaidi Nikhat F, Dave Roshni, Schlosser Kate A, Bandopadhyay Rina, Gerber Scott A, Liu Min
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) and tau have been identified as risk factors of Parkinson's disease (PD). As LRRK2 is a kinase and tau is hyperphosphorylated in some LRRK2 mutation carriers of PD patients, the obvious hypothesis is that tau could be a substrate of LRRK2. Previous reports that LRRK2 phosphorylates free tau or tubulin-associated tau provide direct support for this proposition. By comparing...
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