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The AT-hook DNA binding ability of the Epstein Barr virus EBNA1 protein is necessary for the maintenance of viral genomes in latently infected cells

29 Jun 2015

Abstract excerpt

Epstein Barr Virus (EBV) is a human tumor virus that is causally linked to malignancies such as Burkitt׳s lymphoma, and gastric and nasopharyngeal carcinomas. Tethering of EBV genomes to cellular chromosomes is required for the synthesis and persistence of viral plasmids in tumor cells. However, it is not established how EBV genomes are tethered to cellular chromosomes. We test the hypothesis that the viral...

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PMID: 26122471
DOI: 10.1016/j.virol.2015.05.018

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The AT-hook DNA binding ability of the Epstein Barr virus EBNA1 protein is necessary for the maintenance of viral genomes in latently infected cellsPMID 26122471Read ↗

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Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of <i>oriP</i> Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1Semantic proximity Read ↗

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