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Article

Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance.

The Journal of biological chemistry - 16 Aug 2013

Kanda Teru, Horikoshi Naoki, Murata Takayuki, Kawashima Daisuke, Sugimoto Atsuko, Narita Yohei, Kurumizaka Hitoshi, Tsurumi Tatsuya

Abstract excerpt

The Epstein-Barr virus (EBV) genome is episomally maintained in latently infected cells. The viral protein EBNA1 is a bridging molecule that tethers EBV episomes to host mitotic chromosomes as well as to interphase chromatin. EBNA1 localizes to cellular chromosomes (chromatin) via its chromosome binding domains (CBDs), which are rich in glycine and arginine residues. However, the molecular mechanism by which the...

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Identifiers

PMID: 23836915
DOI: 10.1074/jbc.M113.491167
PMCID: PMC3745364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction between basic residues of Epstein-Barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance.PMID 23836915Read ↗

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