Article
High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort.
PloS one - 1 Jan 2015
Sorbye Halfdan, Dragomir Anca, Sundström Magnus, Pfeiffer Per, Thunberg Ulf, Bergfors Monica, Aasebø Kristine, Eide Geir Egil, Ponten Fredrik, Qvortrup Camilla, Glimelius Bengt
Abstract excerpt
RAS and BRAF mutations impact treatment and prognosis of metastatic colorectal cancer patients (mCRC), but the knowledge is based on trial patients usually not representative for the general cancer population. Patient characteristics, treatment and efficacy according to KRAS, BRAF and MSI status were analyzed in a prospectively collected unselected population-based cohort of 798 non-resectable mCRC patients. The...
Topics
- Aged
- Colorectal Neoplasms
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Multivariate Analysis
- Mutation
- Mutation Rate