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Article

Treatment options in BRAF-mutant metastatic colorectal cancer.

Anti-cancer drugs - 1 Jul 2020

Bernabe-Ramirez Carolina, Patel Rajvi, Chahal Jaspreet, Saif Muhammad Wasif

Abstract excerpt

B-type Raf kinase (BRAF) mutations occur in approximately 10% of patients with metastatic colorectal cancers (mCRC). Tumors harboring this mutation have a unique molecular profile and clinical phenotype. Response rate to systemic chemotherapy is poor and associated with shorter survival rate. Although BRAF inhibition dramatically changed treatment for melanoma patients, similar clinical responses were not...

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Identifiers

PMID: 32304411
DOI: 10.1097/CAD.0000000000000940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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