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Article

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies.

Nature medicine - 1 Jul 2015

Cho Judy H, Feldman Marc

Abstract excerpt

Recent advances in genome-wide association studies (GWAS) across autoimmune and immune-mediated diseases have augmented our understanding of pathogenic mechanisms underlying these diseases. This has further highlighted their heterogeneous nature, both within and between diseases. Furthermore, varying responses to therapy have also served to underline the importance of this heterogeneity in the manner in which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26121193
DOI: 10.1038/nm.3897
PMCID: PMC5716342

Genes

PTPN22
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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