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Article

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

American journal of respiratory cell and molecular biology - 1 Feb 2016

Saini Yogesh, Wilkinson Kristen J, Terrell Kristy A, Burns Kimberlie A, Livraghi-Butrico Alessandra, Doerschuk Claire M, O'Neal Wanda K, Boucher Richard C

Abstract excerpt

Resident immune cells (e.g., macrophages [MΦs]) and airway mucus clearance both contribute to a healthy lung environment. To investigate interactions between pulmonary MΦ function and defective mucus clearance, a genetic model of lysozyme M (LysM) promoter-mediated MΦ depletion was generated, characterized, and crossed with the sodium channel β subunit transgenic (Scnn1b-Tg) mouse model of defective mucus...

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Identifiers

PMID: 26121027
DOI: 10.1165/rcmb.2014-0111OC
PMCID: PMC4821038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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