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Article

CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2018

Chung Man Ki, Jung Young Ho, Lee Joon Kyoo, Cho Soo Youn, Murillo-Sauca Oihana, Uppaluri Ravindra, Shin June Ho, Sunwoo John B

Abstract excerpt

Purpose: Head and neck squamous cell carcinoma (HNSCC) is comprised of heterogeneous populations of cells, and CD271 (NGFR; p75NTR) has been associated with a tumor-initiating cell subpopulation. This study assessed the role of CD271 in modulating metastatic behavior in HNSCC.Experimental Design: CD271 was overexpressed in murine and human oral squamous cell carcinoma cells to assess the impact of CD271...

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Source

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Identifiers

PMID: 29208672
DOI: 10.1158/1078-0432.CCR-17-0866
PMCID: PMC6713647

Genes

NGF
NGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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