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Article

Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.

Structure (London, England : 1993) - 4 Aug 2015

Park Eunyoung, Graziano Brian R, Zheng Wei, Garabedian Mikael, Goode Bruce L, Eck Michael J

Abstract excerpt

In budding yeast, the actin-binding protein Bud6 cooperates with formins Bni1 and Bnr1 to catalyze the assembly of actin filaments. The nucleation-enhancing activity of Bud6 requires both a "core" domain that binds to the formin and a "flank" domain that binds monomeric actin. Here, we describe the structure of the Bud6 flank domain in complex with actin. Two helices in Bud6(flank) interact with actin; one binds...

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Identifiers

PMID: 26118535
DOI: 10.1016/j.str.2015.05.015
PMCID: PMC4578302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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