Article
Structural effects of linkage disequilibrium on the transcriptome.
RNA (New York, N.Y.) - 1 Jan 2012
Martin Joshua S, Halvorsen Matthew, Davis-Neulander Lauren, Ritz Justin, Gopinath Chetna, Beauregard Arthur, Laederach Alain
Abstract excerpt
A majority of SNPs (single nucleotide polymorphisms) map to noncoding and intergenic regions of the genome. Noncoding SNPs are often identified in genome-wide association studies (GWAS) as strongly associated with human disease. Two such disease-associated SNPs in the 5' UTR of the human FTL (Ferritin Light Chain) gene are predicted to alter the ensemble of structures adopted by the mRNA. High-accuracy single...
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