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Predicting functional riboSNitches in the context of alternative splicing.

Gene - 30 Aug 2022

G Ramya, Mitra Abhijit, Pk Vinod

Abstract excerpt

RNAs are the major regulators of gene expression, and their secondary structures play crucial roles at different levels. RiboSNitches are disease-associated SNPs that cause changes in the pre-mRNA secondary structural ensemble. Several riboSNitches have been detected in the 5' and 3' untranslated regions and lncRNA. Although cases of secondary structural elements playing a regulatory role in alternative splicing...

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PMID: 35738445
DOI: 10.1016/j.gene.2022.146694

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