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A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins

25 Jun 2015

Abstract excerpt

BACKGROUND: Polybasic cleavage sites of the hemagglutinin (HA) proteins are considered to be the most important determinants indicating virulence of the avian influenza viruses (AIV). However, evidence is accumulating that these sites alone are not sufficient to establish high pathogenicity. There need to exist other sites located on the HA protein outside the cleavage site or on the other proteins expressed by...

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PMID: 26112351
DOI: 10.1186/s12866-015-0465-x

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