Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses

Abstract excerpt

BACKGROUND: The 1918 H1N1 virus was a highly virulent strain that killed 20-50 million people. The cause of its virulence remains poorly understood. METHODS: Intrinsic disorder predictor PONDR VLXT was used to compare various influenza subtypes and strains. Three-dimensional models using data from X-ray crystallographic studies annotated with disorder prediction were used to characterize the proteins. RESULTS:...

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