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Article

The use of pyrosequencing for detection of hemagglutinin mutations associated with increased pathogenicity of H5N1 avian influenza viruses in mammals.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc - 1 Jul 2018

Wang Chenxi, Zhang Yongning, Bing Guoxia, Zhang Xuxiao, Wang Caixia, Wang Mingyang, Sun Yipeng, Wu Shaoqiang, Lin Xiangmei, Pu Juan, Liu Jinhua, Sun Honglei

Abstract excerpt

Hemagglutinin (HA) cleavage is critical for virulence of influenza viruses. The amino acid residue at the P6 position of the HA cleavage site (HACS) has been shown to be most variable and to have a direct correlation with the cleavage efficiency and pathogenicity of H5N1 avian influenza viruses (AIVs) in mammals. Among these amino acid variants, serine has been associated with the highest virulence in mammals,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29633913
DOI: 10.1177/1040638718769951
PMCID: PMC6505906

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