Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.

Protein and peptide letters - 1 Jan 2016

Kato Yusuke S, Fukui Kiyoshi, Suzuki Kazuo

Abstract excerpt

Avian influenza H5N1 has shown high mortality rate in human. Non-structural protein 1 (NS1) is a virulence factor of H5N1. Mutation at the 42nd residue within the RNA-binding domain (RBD) of NS1 dramatically changes the degree of pathogenicity of H5N1 in mice. We here studied the impact of this mutation on the function of RBD, and found that RBD with serine at the 42th residue binds double-stranded RNA (dsRNA),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Circular Dichroism
Share to Influenza A Virus, H5N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Protein Structure, Tertiary

Share to Viral Nonstructural Proteins

Share to Virulence

Source

Identifiers

PMID: 26845765
DOI: 10.2174/0929866523666160204124406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.PMID 26845765Read ↗

A Single-Amino-Acid Substitution in the NS1 Protein Changes the Pathogenicity of H5N1 Avian Influenza Viruses in MiceSemantic proximity Read ↗

Structure and Function of the NS1 Protein of Influenza A VirusSemantic proximity Read ↗

Structural and functional analysis of NS1 and NS2 proteins of H1N1 subtype.Semantic proximity Read ↗

Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in MiceSemantic proximity Read ↗

NS1: A Key Protein in the “Game” Between Influenza A Virus and Host in Innate ImmunitySemantic proximity Read ↗

H5N1 avian influenza virus without 80–84 amino acid deletion at the NS1 protein hijacks the innate immune system of dendritic cells for an enhanced mammalian pathogenicitySemantic proximity Read ↗

Synergistic effect of PB2 283M and 526R contributes to enhanced virulence of H5N8 influenza viruses in miceSemantic proximity Read ↗

The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins.Semantic proximity Read ↗

Deep sequencing of the transcriptome from murine lung infected with H5N8 subtype avian influenza virus with combined substitutions I283M and K526R in PB2 gene.Semantic proximity Read ↗

A single-amino-acid substitution in the HA protein changes the replication and pathogenicity of the 2009 pandemic A (H1N1) influenza viruses in vitro and in vivoSemantic proximity Read ↗

Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain.Semantic proximity Read ↗

Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.