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Article

The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen.

Molecular microbiology - 1 Jun 2000

Kehres D G, Zaharik M L, Finlay B B, Maguire M E

Abstract excerpt

NRAMPs (natural resistance-associated macrophage proteins) have been characterized in mammals as divalent transition metal transporters involved in iron metabolism and host resistance to certain pathogens. The mechanism of pathogen resistance is proposed to involve sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage...

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PMID: 10844693
DOI: 10.1046/j.1365-2958.2000.01922.x

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