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Article

A Morbillivirus Infection Shifts DC Maturation Toward a Tolerogenic Phenotype to Suppress T Cell Activation.

Journal of virology - 28 Sept 2022

Rodríguez-Martín Daniel, García-García Isabel, Martín Verónica, Rojas José Manuel, Sevilla Noemí

Abstract excerpt

Viruses have evolved numerous strategies to impair immunity so that they can replicate more efficiently. Among those, the immunosuppressive effects of morbillivirus infection can be particularly problematic, as they allow secondary infections to take hold in the host, worsening disease prognosis. In the present work, we hypothesized that the highly contagious morbillivirus peste des petits ruminants virus (PPRV)...

Topics

Animals
Antiviral Agents
Cell Differentiation
Concanavalin A
Dendritic Cells
Goats
Immunosuppression Therapy
Lymphocyte Activation
Mitogens
Peste-des-Petits-Ruminants
Peste-des-petits-ruminants virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Sheep

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 36094317
DOI: 10.1128/jvi.01240-22
PMCID: PMC9517701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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