Article
Association of GSTO2 (N142D), GSTT1, and GSTM1 Polymorphisms With Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant Recipients.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Aug 2016
Khosravi Maryam, Izaddoust Mansoureh, Saadat Iraj, Karimi Mohammad Hossein, Ramzi Mani
Abstract excerpt
OBJECTIVES: Graft-versus-host disease is a major problem after bone marrow transplant. GSTM1, GSTT1, and GSTO2 are important genes that interfere with xenobiotic and drug metabolism. Polymorphisms of these genes may influence the metabolism of immunosuppressive drugs given for inhibition of graft-versus-host disease and may influence their susceptibility to diseases, which bone marrow transplant could alleviate....
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