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A UGT2B17‐positive donor is a risk factor for higher transplant‐related mortality and lower survival after bone marrow transplantation

1 Apr 2005

Abstract excerpt

We recently identified a human minor histocompatibility (H) antigen, encoded by UDP glycosyltransferase 2 family, polypeptide B17 (UGT2B17), whose immunogenicity results from differential expression in donor and recipient cells as a consequence of a homozygous deletion of the UGT2B17 gene. UGT2B17 is highly expressed in the liver and colon, which are major targets for graft-versus-host disease (GVHD). To assess...

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PMID: 15813850
DOI: 10.1111/j.1365-2141.2005.05427.x

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