Article
SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity.
Nucleic acids research - 27 Jul 2015
Seamon Kyle J, Sun Zhiqiang, Shlyakhtenko Luda S, Lyubchenko Yuri L, Stivers James T
Abstract excerpt
The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this established activity, there have been a series of conflicting reports as to whether the enzyme also possesses single-stranded DNA and/or RNA 3'-5' exonuclease activity. SAMHD1 was purified using three chromatography steps, over which the DNase...
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