Article
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Nature communications - 2 Feb 2021
Yu Corey H, Bhattacharya Akash, Persaud Mirjana, Taylor Alexander B, Wang Zhonghua, Bulnes-Ramos Angel, Xu Joella, Selyutina Anastasia, Martinez-Lopez Alicia, Cano Kristin, Demeler Borries, Kim Baek, Hardies Stephen C, Diaz-Griffero Felipe, Ivanov Dmitri N
Abstract excerpt
SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein-dephosphorylation of deoxynucleotide triphosphates (dNTPs)-implicates enzymatic dNTP depletion in innate antiviral immunity. Here we show that the allosteric binding sites of the enzyme are plastic and can accommodate oligonucleotides in place of the allosteric activators, GTP and dNTP....
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