Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosis

3 Mar 2015

Abstract excerpt

T helper 17 (T(H)17) cells, a subset of CD4+ T cells that secrete the proinflammatory cytokine interleukin-17 (IL-17), play a key pathogenic role in autoimmune diseases. Through inducible and tissue-specific deletion systems, we described the time- and tissue-specific roles of the mitogen-activated protein kinase (MAPK) p38α in mediating T(H)17 cell-induced tissue inflammation. Inducible deletion of Mapk14 (which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to NF-κB Signaling Pathways
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25737586
DOI: 10.1126/scisignal.aaa2147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosisPMID 25737586Read ↗

Cutting Edge: TNF Receptor-Associated Factor 4 Restricts IL-17–Mediated Pathology and Signaling ProcessesSemantic proximity Read ↗

The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis.Semantic proximity Read ↗

IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating diseaseSemantic proximity Read ↗

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple SclerosisSemantic proximity Read ↗

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Semantic proximity Read ↗

Roles of T helper 17 cells and interleukin‐17 in neuroautoimmune diseases with emphasis on multiple sclerosis and Guillain‐Barré syndrome as well as their animal modelsSemantic proximity Read ↗

The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism.Semantic proximity Read ↗

Interleukin-36γ–producing macrophages drive IL-17–mediated fibrosisSemantic proximity Read ↗

Immunoregulatory effects of interferon-β in suppression of Th17 cells.Semantic proximity Read ↗

p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine productionSemantic proximity Read ↗

Beta Adrenergic Signaling as a Therapeutic Target for AutoimmunitySemantic proximity Read ↗

S1P1 deletion differentially affects TH17 and Regulatory T cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.