Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+T Cells of Patients with Relapsing-Remitting Multiple Sclerosis

Abstract excerpt

MicroRNAs (miRNAs) are a family of noncoding RNAs that play critical roles in the posttranscriptional regulation of gene expression. Accumulating evidence supports their involvement in the pathogenesis of multiple sclerosis (MS). Here, we compare miR-17 expressions in CD4+ T cells from relapsing-remitting (RR) MS patients treated with natalizumab versus untreated patients. miR-17 was downregulated under...

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