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Article

First description of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in France.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Lavergne Rose-Anne, Morio Florent, Favennec Loïc, Dominique Stéphane, Meis Jacques F, Gargala Gilles, Verweij Paul E, Le Pape Patrice

Abstract excerpt

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25918139
DOI: 10.1128/AAC.00127-15
PMCID: PMC4468656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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