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Article

CYP2A6 genetic polymorphism is associated with decreased susceptibility to squamous cell lung cancer in Japanese smokers.

Drug metabolism and pharmacokinetics - 1 Aug 2015

Hosono Hiroki, Kumondai Masaki, Arai Tomio, Sugimura Haruhiko, Sasaki Takamitsu, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Cytochrome P450 2A6 (CYP2A6) is an enzyme involved in the metabolism of tobacco carcinogens, which are important risk factors in lung cancer. We and others have previously reported that CYP2A6*4, a whole-gene deletion polymorphism, is associated with lower risk of lung cancer than the wild-type allele. However, the genotyping method used in these previous studies considered only the CYP2A6*4 allele; this lead to...

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Identifiers

PMID: 26091970
DOI: 10.1016/j.dmpk.2015.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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