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Article

Genomic data integration in chronic lymphocytic leukemia.

The journal of gene medicine - 1 Jan 2017

Fernández-Martínez Juan Luis, deAndrés-Galiana Enrique J, Sonis Stephen T

Abstract excerpt

BACKGROUND: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous disease and the most common adult leukemia in western countries. IgVH mutational status distinguishes two major types of CLL, each associated with a different prognosis and survival. Sequencing identified NOTCH1 and SF3B1 as the two main recurrent mutations. We described a novel method to clarify how these mutations affect gene expression by...

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Topics

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Share to Databases, Nucleic Acid
Share to Gene Regulatory Networks
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Phosphoproteins

Share to Principal Component Analysis

Share to Receptors, Notch

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Source

Identifiers

PMID: 27928896
DOI: 10.1002/jgm.2936

Genes

NOTCH1
LPL
LTK
MSI2
MYBL1
NRIP1
PLAGL1
RGS1
RPL32
TFEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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