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Article

Unique requirements for mono- and polyubiquitination of the peroxisomal targeting signal co-receptor, Pex20.

The Journal of biological chemistry - 8 Mar 2013

Liu Xueqian, Subramani Suresh

Abstract excerpt

In Pichia pastoris, the peroxisomal targeting signal 2 (PTS2)-dependent peroxisomal matrix protein import pathway requires the receptor, Pex7, and its co-receptor Pex20. A conserved lysine (Lys(19)) near the N terminus of Pex20 is required for its polyubiquitination and proteasomal degradation, whereas a conserved cysteine (Cys(8)) is essential for its recycling. In this study, we found that Cys(8) is required...

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Identifiers

PMID: 23344950
DOI: 10.1074/jbc.M112.424911
PMCID: PMC3591631

Genes

PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Unique requirements for mono- and polyubiquitination of the peroxisomal targeting signal co-receptor, Pex20.PMID 23344950Read ↗

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Cysteine-dependent ubiquitination of Pex18p is linked to cargo translocation across the peroxisomal membrane.Semantic proximity Read ↗

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Ubiquitination of the peroxisomal import receptor Pex5p.Semantic proximity Read ↗

The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells.Semantic proximity Read ↗

Genetic Interactions between PEROXIN12 and Other Peroxisome-Associated Ubiquitination Components.Semantic proximity Read ↗

Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane.Semantic proximity Read ↗

CUL4A-DDB1-Rbx1 E3 ligase controls the quality of the PTS2 receptor Pex7p.Semantic proximity Read ↗

Pex18p is constitutively degraded during peroxisome biogenesis.Semantic proximity Read ↗

Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.Semantic proximity Read ↗

TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import.Semantic proximity Read ↗

The import receptor Pex7p and the PTS2 targeting sequence.Semantic proximity Read ↗

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